Retroviruses can take up cellular genes, which are modified to become oncogenes and cause cancer in animals. Such oncogenes were the bases for cancer research for several decades. We used a universal approach to isolate and characterize oncogene proteins with a monoclonal antibody against a fusion protein linked to viral oncoproteins. By this approach we isolated and characterized the Myc protein as nuclear transcription factor, Myb, ErbB and the Raf kinase. Raf kinase was a focus of research, most importantly a cross-talk with the Akt kinase, led to novel results, indicating that Raf is not only active in growth promotion but also in differentiation. Furthermore we studied oncogenes like Tax, Bcr-Abl, telomerase, and most recently Src. We showed that a single point mutation at the very C-terminus of Src leads to metastasis formation due to loss of binding to a tumor suppressor PDZ protein.
Publications about oncogenes and cancer
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- ***Donner, P., Greiser-Wilke, I. and Moelling, K. Nuclear localization and DNA-binding of the transforming gene product of avian myelocytomatosis virus. Nature 296, 262-266 (1982).
- *Bunte, T., Greiser-Wilke, I., Donner, P. and Moelling, K. Association of gag-myc proteins from avian myelocytomatosis virus wild-type and mutants with chromatin. EMBO J. 1, 919-927 (1982).
- Bunte, T. and Moelling, K. Analysis of two phosphoproteins related to pp60src from Schmidt-Ruppin D virus particles. J. Gen. Virol. 64, 723-726 (1983).
- Moelling, K., Owada, M.K., Greiser-Wilke, I., Bunte, T. and Donner, P. Biochemical characterization of transformation-specific proteins of acute avian leukemia and sarcoma viruses. J. Cell. Biochem. 20, 63-69 (1982).
- Moelling, K., Greiser-Wilke, I., Owada, M.K., Donner, P. and Bunte, T. DNA-binding ability of transforming proteins from avian erythroblastosis virus and mutant avian myelocytomatosis virus, MC29, in comparison with MC29 wild type. In: Haematology and Blood Transfusion, Vol. 28, “Modern Trends in Human Leukemia V”, Eds. Neth, Gallo, Greaves, Moore, Winkler. Springer-Verlag, Berlin-Heidelberg, pp. 214-217 (1983).
- ***Donner, P., Bunte, T., Greiser-Wilke, I. and Moelling, K. Decreased DNA-binding ability of purified transformation-specific proteins from deletion mutants of the acute avian leukemia virus MC29. Proc. Natl. Acad. Sci. USA 80, 2861-2865 (1983).
- *Bunte, T., Greiser-Wilke, I. and Moelling, K. The transforming protein of the MC29-related virus CMII is a nuclear DNA-binding protein whereas MH2 codes for a cyto-plasmic RNA-DNA binding polyprotein. EMBO J. 2, 1087-1092 (1983).
- Moelling, K. Molecular mechanisms of malignant transformation by oncornaviruses. In: “Mechanisms of B Cell Neoplasia”. Eds. F. Melchers, M. Potter, M. Weigert, Edition Roche, Basel, pp. 307-316 (1983).
- Moelling, K., Donner, P., Bunte, T. and Greiser-Wilke, I. Molecular mechanisms of malignant transformation by oncornaviruses. In: “Contributions to Oncology”, Vol. 19, “Genes and Antigens in Cancer Cells – The Monoclonal Antibody Approach”. Eds. G. Riethmüller, H. Koprowski, S. von Kleist, K. Munk. Karger, Basel, pp. 35-43 (1984).
- *Bunte, T., Donner, P., Pfaff, E., Reis, B., Greiser-Wilke, I., Schaller, H. and Moelling, K. Inhibition of DNA binding of purified p55v-myc in vitro by antibodies against bacterially expressed myc protein and a synthetic peptide. EMBO J. 3, 1919-1924 (1984).
- Moelling, K., Benter, T., Bunte, T., Pfaff, E., Deppert, W., Egly, J.M. and Miyamoto, N.B. Properties of the myc-gene product: Nuclear association, inhibition of transcription and activation in stimulated lymphocytes. Curr. Top. Microbiol. Immunol. 113, 198-207 (1984).
- Moelling, K., Bunte, T., Greiser-Wilke, I., Donner, P. and Pfaff, E. Properties of the avian viral transforming proteins gag-myc, myc, and gag-mil. In: “Cancer Cells, Vol. 2, Oncogenes and Viral Genes”, Eds. G.F. van de Woude, A.J. Levine, W.C. Topp, J.D. Watsons. Cold Spring Harbor Laboratory, pp. 173-180 (1984).
- ***Moelling, K., Heimann, B., Beimling, P., Rapp, U.R. and Sander, T.: Serine- and threonine-specific protein kinase activities of purified gag-mil and gag-raf proteins. Nature 312, 558-561 (1984).
- Moelling, K.: Fusion proteins in retroviral transformation. In: “Advances in Cancer Research”, Vol. 43. Eds. G. Klein, S. Weinhouse, Academic Press, New York, pp. 205-239 (1985).
- **Moelling, K., Pfaff, E., Beug, H., Beimling, P., Bunte, T., Schaller, H.E. and Graf, T. DNA-binding activity is associated with purified myb proteins from AMV and E26 viruses and is temperature-sensitive for E26 ts mutants. Cell 40, 983-990 (1985).
- Benter, T., Beimling, P., Pfaff, E., Sander, T., Heimann, B. and Moelling, K. Identification of the human cellular myc gene product by antibody against the bacterially expressed protein. In: Haematology and Blood Transfusion, Vol. 29. “Modern Trends in Human Leukemia VI”, Eds. R. Neth, R.C. Gallo, M.F. Greaves, R. Janka. Springer-Verlag, Berlin-Heidelberg, pp. 266-268 (1985).
- Heimann, B., Beimling, P., Pfaff, E., Schaller, H. and Moelling, K. Analysis of a tyrosine-specific protein kinase activity associated with the retroviral erbB oncogene product. Exp. Cell Res. 161, 199-208 (1985).
- Beimling, P., Benter, T., Sander, T. and Moelling, K. Isolation and characterization of the human cellular myc gene product. Biochemistry 24, 6349-6355 (1985).
- Moelling, K., Sander, T., Lorenz, U., Beimling, P. and Bading, H. Interaction of the oncogene protein myc with specific DNA fragments. J. Cancer Res. Clin. Oncol. 112, 97-99 (1986).
- Moelling, K. Properties of the myc and myb gene products. In: “Oncogenes and Growth Control”, Eds. P. Kahn, T. Graf. Springer-Verlag, Berlin-Heidelberg, pp. 271-277 (1986).
- Moelling, K., Lorenz, U., Beimling, P., Heimann, B., Thomas, G., Bading, H. and Sander, T. Biochemical properties of oncogene-coded proteins. In: “Cell Cycle and Oncogenes”, Springer-Verlag, Berlin-Heidelberg, pp. 105-113 (1986).
- Moelling, K., Heimann, B., Beimling, P., Bepler, G., Köppler, H., Havemann, K. and Balzer, T. Analysis of oncogene proteins in human cell tumor lines. In: “Contributions to Oncology”, Eds. S. Eckhards, J.W. Holzner, G. Nagel, Vol. 24. Eds. P.H. Hofschneider, K. Munk. Karger, Basel, pp. 76-86 (1987).
- Bading, H., Hansen, J. and Moelling, K. Selective DNA binding of the human cellular myb protein isolated by immunoaffinity chromatography using a monoclonal antibody. Oncogene 1, 395-401 (1987).
- Moelling, K., Heimann, B., Bading, H., Häder, M., Bepler, G., Havemann, K. and Beutler, C. Proteins of oncogenes in human tumor cells. In: “Modulation of Liver Cell Expression”, Eds. W. Reutter, H. Popper, I.M. Arias, P.C. Heinrich, D. Keppler, L. Landmann. MTP Press Ltd., Lancaster, England, pp. 275-285 (1987).
- Bading, H., Beutler, C., Beimling, P., Gerdes, J., Stein, H. and Moelling, K. Monoclonal antibodies against the viral and human cellular myb-gene product. In: Haematology and Blood Transfusion, Vol. 31. “Modern Trends in Human Leukemia VII”, Eds. R. Neth, R.C. Gallo, M.F. Greaves, H. Kabisch. Springer-Verlag, Berlin-Heidelberg, pp. 488-492 (1987).
- Häder, M., Stach-Machado, D., Pflüger, K.-H., Rotsch, M., Heimann, B., Moelling, K. and Havemann, K. Epidermal growth factor receptor expression, proliferation, and colony stimulating activity production in the urinary bladder carcinoma cell line 5637. J. Cancer Res. Clin. Oncol. 113, 579-585 (1987).
- **Denhez, F., Heimann, B., d’Auriol, L., Graf, T., Coquillaud, M., Coll, J., Galibert, F., Moelling, K., Stehelin, D. and Ghysdael, J. Replacement of lys 622 in the ATP binding domain of P100gag-mil abolishes the in vitro autophosphorylation of the protein and the biological properties of the v-mil oncogene of MH2 virus. EMBO J. 7, 541-546 (1988).
- Bading, H., Gerdes, J., Schwarting, R., Stein, H. and Moelling, K. Nuclear and cytoplasmic distribution of cellular myb protein in human haematopoietic cells evidenced by monoclonal antibody. Oncogene 3, 257-265 (1988).
- Müller, R., Klempnauer, K.-H., Moelling, K., Beug, H. and Vennström, B. Cellular oncogenes encoding nuclear proteins: fos, myb, myc and erbA. In: “Cellular Oncogene Activation”. Ed. Klein, G., Marcel Dekker, Inc., New York, Basel, pp. 1-54 (1988).
- Denhez, F., Galibert, F., Heimann, B., Dozier, C., Graf, T., Moelling, K., Stehelin, D. and Ghysdael, J. An invariant asparagine residue belonging to a highly conserved domain in all protein kinases is instrumental in the protein kinase activity of the v-mil gene product. Oncogene Research 3, 199-205 (1988).
- Bazin, H., Chattopadhyaya, J., Datema, R., Ericson, A.-C., Gilljam, G., Johansson, N.G., Hansen, J., Koshida, R., Moelling, K., Öberg, B., Remaud, G., Stening, G., Vrang, L., Wahren, B. and Wu, J.C. An analysis of the inhibition of replication of HIV and MULV by some 3′-blocked pyrimidine analogs. Biochemical Pharmacology 38, 109-119 (1989).
- Bepler, G., Bading, H., Heimann, B., Kiefer, P, Havemann, K. and Moelling, K. Expression of p64c-myc and neuroendocrine properties define three subclasses of small cell lung cancer. Oncogene 4, 45-50 (1989).
- Bading, H., Beutler, C. and Moelling, K. Mapping of a small phosphopeptide at the carboxyterminus of the viral myb protein by monoclonal antibodies. Oncogene 4, 33-38 (1989).
- *Beimling, P. and Moelling, K. Isolation and characterization of the tax-protein of HTLV-I. Oncogene 4, 511-516 (1989).
- Bading, H., Rauterberg, E.W. and Moelling, K. Distribution of c-myc, c-myb, and Ki 67 antigen in interphase and mitotic human cells evidenced by immunofluorescence staining technique. Experim. Cell Res. 185, 50-59 (1989).
- Beimling, P. and Moelling, K. Tax-independent binding of multiple cellular factors to Tax-response element DNA of HTLV-I. Oncogene 5, 361-368 (1990).
- *Kalkbrenner, F., Guehmann, S., and Moelling, K. Transcriptional activation by human c-myb and v-myb genes.
- Haeder, M., Rotsch, M., Bepler, G., Hennig, C., Havemann, K., Heimann, B. and Moelling, K. Epidermal growth factor receptor expression in human lung cancer cell lines. Cancer Research 48, 1132-1136 (1988).
- Kalthoff, H., Röder, C., Schewe, K., Schmiegel, W., Thiele, H.-G., Heimann, B., Bading, H., Schramm, K. and Moelling, K. Analysis of c-raf-oncogene expression in gastrointestinal tumor cells. In: Modern Trends in Human Leukaemia, VIII, Ed. R. Neth, p. 436-439 (1989).
- Bading, H. and Moelling, K. Transcriptional down-regulation of c-myc expression by protein synthesis-dependent and -independent pathways in a human T-lymphoblastic tumor cell line. Cell Growth and Differentiation 1, 113-117 (1990).
- Lorenz, U., Sock, E., Grummt, F. and Moelling, K. Analysis of DNA sequences present in complexes of v-Myc and cellular DNA. Oncogene 6, 51-57 (1991).
- Zobel, A., Kalkbrenner, F., Guehmann, S., Nawrath, M., Vorbrueggen, G. and Moelling, K. Interaction of the v- and c-Myb proteins with regulatory sequences of the human c-myc gene: Oncogene 6, 1397-1407 (1991).
- *Beimling, P. and Moelling, K. Direct interaction of CREB protein with 21 bp Tax-response elements of HTLV-1 LTR. Oncogene 7, 257-262 (1992).
- Bouwmeester, T., Guehmann, S., El-Baradi, T., Kalkbrenner, F., van Wijk, I., Moelling, K. and Pieler, T. Molecular cloning, expression and in vitro functional characterization of myb-related proteins in Xenopus. Mech. of Developm. 37, 57-68 (1992).
- Zobel, A., Kalkbrenner, F., Vorbrueggen, G. and Moelling, K. Transactivation of the human c-myc gene by c-Myb. Biochem. Biophys. Res. Commun. 186, 715-722 (1992).
- *Guehmann, S., Vorbrueggen, G, Kalkbrenner, F. and Moelling, K. Reduction of a conserved cys is essential for Myb-DNA binding. Nucl. Acid Res. 20, 2279-2286 (1992).
- Pachuk, C.J., Yoon, K., Moelling, K., Coney, L.R. Selective cleavage of bcr-abl chimeric RNAs by a ribozyme targeted to non-contiguous sequences. Nucl. Acid. Res. 22, 301-307 (1994).
- Moelling, K., Mueller, G., Dannull, J., Reuss, C., Beimling, P., Bartz, C., Wiedenmann, B., Yoon, K., Surovoy, A. and Jung, G. Stimulation of Ki-ras ribozyme activity by RNA binding protein NCp7 in vitro and in pancreatic tumor cell line Capan 1. In: “Molecular and Cell Biological Aspects of Gastroenteropancreatic Neuroendocrine Tumor Disease”: (B. Wiedenmann, L.K. Kvols, R. Arnold, E.O. Riecken, eds.) Annals of the New York Academy of Sciences 733, 113-121 (1994).
- Lovric, J., Bischoff, O. and Moelling, K. Cell cycle-dependent association of Gag-Mil and hsp90. FEBS Letters 343, 15-21 (1994).
- Schramm, K., Niehof, M., Radziwill, G., Rommel, C. and Moelling, K. Phosphorylation of c-Raf-1 by protein kinase A interferes with activation. Biochem. Biophys. Res. Com. 201, 740-747 (1994).
- Vorbrüggen, G., Kalkbrenner, F., Guehmann, S. and Moelling, K. The carboxyterminus of human c-myb protein stimulates activated transcription in trans. Nucleic Acids Res. 22, 2466-2475 (1994).
- Beimling, P., Niehof, M., Radziwill, G. and Moelling, K. The aminoterminus of c-Raf-1 binds a protein kinase phosphorylation Ser259. Biochem. Biophys. Res. Com. 204, 841-848 (1994).
- **Radziwill, G., Niehof, M., Rommel, C. and Moelling, K. Direct interaction and aminoterminal phosphorylation of c-Jun by c-Mil/Raf. Proc. Natl. Acad. Sci. USA 92, 1421-1425 (1995).
- Nuernberg, W., Artuc, M., Vorbrueggen, G., Kalkbrenner, F., Moelling, K., Czarnetzki, B.M. and Schadendorf, D. Nuclear proto-oncogene products transactivate the human papillomavirus type 16 promoter. B. J. of Cancer 71, 1018-1024 (1995).
- Goren, I., Semmes, O.J., Jeang, K.T. and Moelling, K. The amino terminus of Tax is required for interaction with the cyclic AMP response element binding protein. J.Virol. 69, 5806-5811 (1995).
- *Rommel, C., Radziwill, G., Lovric’, J., Noeldeke, J., Heinicke, T., Jones, D., Aitken, A. and Moelling, K. Activated Ras displaces 14-3-3 protein from the amino terminus of c-Raf-1. Oncogene 12, 609-619 (1996).
- Lovric’, J. and Moelling, K. Activation of Mil/Raf protein kinases in mitotic cells. Oncogene 12, 1109-1116 (1996).
- Lovric’, J., Radziwill, G. and Moelling, K. Specific association of Mil/Raf proteins with a 34 kDa phospoprotein. Oncogene 12, 1145-1151 (1996).Vorbrueggen, G., Lovric’, J. and Moelling, K. Functional analysis of phosphorylation at serine 532 of human c-Myb by MAP-kinase. Biol. Chem. 377, 721-730 (1996).
- Radziwill, G., Steinhusen, U., Aitken, A. and Moelling, K. Inhibition of Raf/MAPK signaling in Xenopus oocyte extracts by Raf-1 specific peptides. Biochem. Biophys. Res. Com. 227, 20-26(1996).
- *Rommel, C., Radziwill, G., Moelling, K. and Hafen, E. Negative regulation of Raf activity by binding of 14-3-3 to the amino terminus of Raf in vivo. Mechanisms of Development 64, 95-104 (1997).
- Zimmermann S., Rommel C., Ziogas A., Lovric’ J., Moelling K. and Radziwill G. MEK1 mediates a positive feedback on Raf-1 activity independently of Ras and Src. Oncogene 15, 1503-1511 (1997).
- Golay, J., Broccoli, V., Borleri, G.-M., Erba, E., Faretta, M., Basilico, L., Ying, G.-G., Piccinini, G., Shapiro, L.H., Lovric, J., Nawrath M., Moelling, K., Rambaldi, A. and Introna M. Redundant functions of B-Myb and c-Myb in differentiating myeloid cells. Cell Growth and Differentiation, 8 (12), 1305-1316 (1997).
- Ziogas, A., Lorenz, I. C., Moelling K. and Radziwill G. Mitotic Raf-1 is stimulated independently of Ras and is active in the cytoplasm. J. Biol. Chem. 273, 24108-24114 (1998).
- *Buchert, M., Schneider, S., Adams, M., Baechi, T., Moelling, K. and Hovens, C.M. The junction-associated protein AF-6 interacts and clusters with specific Eph receptor tyrosine kinase at specialized sites of cell-cell-contact in the brain. J. Cell Biol 144, 361-371 (1999).
- Kasono, K., Piché, A., Xiang, J., Kim, H., Bilbao, G., Johanning, F., Nawrath, M., Moelling, K. and Curiel, D.T. Functional knock-out of c-myb by an intracellular anti-c-Myb single-chain antibody. Biochem. Biophys. Res. Com., 251, 124-130 (1999).
- ***Lowrie, D.B., Tascon, R.E., Bonato, V.L.D., Lima, V.M.F., Faccioli, L.H., Stavropoulos, E., Colston, M.J., Hewinson, R.G., Moelling, K. and Silva, C.L. Therapy of tuberculosis in mice by DNA vaccination. Nature 400, 269-271 (1999). – Lowrie 1999.pdf
- Heinicke, T., Radziwill, G., Nawrath, M., Rommel, C., Pavlovic, J. and Moelling, K. Retroviral gene transfer of dominant negative Raf-1 mutants suppresses Ha-ras-induced transformation and delays tumor formation. Cancer Gene Therapy 7, 697-706 (2000).
- Heinrich, J., Bosse, M., Eickhoff, H., Nietfeld, W., Reinhardt, R., Lehrach, H. and Moelling, K. Induction of putative tumor-suppressing genes in Rat-1 fibroblasts by oncogenic Raf-1 as evidenced by robot-assisted subtractive hybridization. Journal of Molecular Medicine 78, 380-388 (2000).
- Nawrath, M., Pavlovic, J. and Moelling, K. Inhibition of human hematopoietic tumor formation by targeting a repressor Myb-KRAB to DNA. Cancer Gene Therapy 7, 963-972 (2000).
- ***Rommel, Ch., Clarke, B.A., Zimmermann, S., Nunez, L., Rossman, R., Reid, K., Moelling, K., Yancopoulos, G.D. and Glass, D.J. Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt. Science 286, 1738-1741 (1999). – Rommel 1999.pdf
- ***Zimmermann, S. and Moelling, K. Phosphorylation and regulation of Raf by Akt (protein kinase B). Science 286, 1741-1744 (1999). – Zimmermann 1999.pdf
- *Reusch, H.P., Zimmermann, S., Schaefer, M., Paul, M., Moelling, K. Regulation of Raf by Akt controls growth and differentiation in vascular smooth muscle cells. J. Biol. Chem. 276, 33630-33637 (2001). – Reusch 2001.pdf
- Moelling, K., Schad, K., Bosse, M., Zimmermann, S., Schweneker, M. Regulation of Raf-Akt cross-talk. J. Biol. Chem. 34, 31099-31106 (2002).
- Ladell, K., Heinrich, J., Schweneker, M., Moelling, K. A combination of plasmid DNAs encoding murine Flk-1 extracellular domain, murine IL-12 and murine IP-10 lead to tumor regression and survival in melanoma-bearing mice. J. Mol. Med. 81, 271-278 (2003).
- *Radziwill, G., Erdmann, R.A., Margelisch, U., Moelling K. The Bcr kinase downregulates Ras signaling by phosphorylating AF-6 and binding to its PDZ domain. Molecular and Cellular Biology 23, 13, 4663-4672 (2003).
- Ziogas, A., Moelling, K. and Radziwill, G. CNK1 is a scaffold protein that regulates Src-mediated Raf-1 activation. J Biol Chem. 280, 25, 24205-24211 (2005).
- **Ress, A., Moelling, K. Bcr is a negative regulator of the Wnt signalling pathway. EMBO reports 6, 11, 1095-1100 (2005) – Ress 2005
- Ress, A. and Moelling, K. Bcr interferes with β-catenin-Tcf1 interaction FEBS Letters 580, 1227-1230 (2006).
- *Lorger, M. and Moelling, K. Regulation of epithelial wound closure and cell-cell adhesion by interaction of AF6 with actin cytoskeleton. JCS 119, 3385-3398 (2006) – Lorger 2006
- *Fritzius, Th., Burkard, G., Haas, E., Heinrich, J., Schweneker, M., Bosse, M., Zimmermann, S., Frey, A.D., Caelers, A., Bachmann, A.S. and Moelling, K. A WD-FYVE protein binds to the kinases Akt and PKCζ/λ. Biochemical Journal, 399, 9-20 (2006) – Fritzius 2006
- Usluoglu, N., Pavlovic, J., Moelling, K. and Radziwill, G. RIP2 mediates LPS-induced p-38 and IκBα signaling including IL-12 p40 expression in human monocyte-derived dendritic cells Eur. J. Immunol. 37, 2317-2325 (2007).
- *Radziwill, G., Weiss, A., Heinrich, J., Baumgartner, M., Boisguerin, P., Owada, K. and Moelling, K. Regulation of c-Src by binding to the PDZ domain of AF-6. EMBO J, 26, 2633-2644 (2007). – Radziwill 2007
- Fritzius, Th., Frey, A.D., Schweneker, M., Mayer, D. and Moelling, K. WD- repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Cζ. FEBS Journal 274, 1552-1566 (2007).
- Ortner, E. and Moelling, K. Heteromeric complex formation of ASK2 and ASK1 regulates stress-induced signaling. Biochem. Biophys. Res. Commun. 362, 454–459 (2007) – Ortner 2007
- Weiss, A., Baumgartner, M., Radziwill, G. Dennler, J. and Moelling, K. c-Src is a PDZ-interacting partner and substrate of the E3 ubiquitin ligase ligand-of-numb protein X1. FEBS Lett. 581, 5131-5136 (2007) – Weiss 2007
- *Baumgartner, M., Radziwill, G. Lorger, M., Weiss, A. and Moelling, K. c-Src-mediated epithelial cell migration and invasion regulated by PDZ binding site. Molecular and Cellular Biology, 28, 642-655 (2008) – Baumgartner 2008
- *Fritzius, Th. and Moelling, K. Akt- and Foxo1- interacting WD-repeat-FYVE protein promotes adipogenesis EMBO J 27, 1399-1410 (2008) Fritzius 2008
- Noreen, F., Heinrich, J. and Moelling, K. Anti-tumor activity of small double-stranded oligodeoxynucleotides targeting telomerase RNA in malignant melanoma cells. Oligonucleotides 19:2, 169-178 (2009) – Noreen 2009
- Baumgartner, M., Weiss, A., Fritzius, T., Heinrich, J., and Moelling, K. The PDZ protein MPP2 interacts with c-Src in epithelial cells. Experimental Cell Research 315: 2888-2898 (2009) – Baumgartner 2009
- Hofmann M., Heinrich, J., Radziwill, G., and Moelling, K. A short hairpin DNA analogous to miR125b inhibits C-Raf expression, proliferation and survival in breast cancer cells. Molecular Cancer Research 7, 1635-1644 (2009) – Hofmann 2009
- Vargas, C., Radziwil, G., Krause, G., Diehl, A., Keller, S., Schmieder, P., Doyle, D., Moelling, K., Hagen, V., Schade, M. and Oschkinat, H. Small-molecule inhibitors of AF6-mediated protein-protein interactions (to be resubmitted)